Research staff have found that, among people with more or less frequent stools, specific DNA changes are more common than in the rest of the population. To carry out the research, 167,875 individuals from population cohorts in the United Kingdom (UK Biobank), the Netherlands (LifeLines-Deep), Belgium (Flemish Gut Flora Project), Sweden (PopCol) and the United States (Genes for Good), and their genetic makeup has been correlated with the questionnaire data, mainly in relation to a simple query about the number of times one opens the intestines every day (the "stool frequency", as they called it in the study). The discovery of genes that control bowel habits opens the door to new therapeutic targets for irritable bowel.
An international team coordinated by Mauro D'Amato, Ikerbasque research professor at CIC bioGUNE, has shown for the first time that the frequency of defecation is hereditary in humans, and that specific genetic profiles influence intestinal habits, as well as predisposition to irritable bowel syndrome.
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